As a Loyola student, you have the opportunity to work alongside our talented professors to partner in collaborative research. Learn more about some recent research and projects currently underway.
Dr. Hillary Eklund:
Dr. Christopher Schaberg:
All living cells in order to survive and to perform their physiological functions continuously exchange various atoms and molecules with the extracellular medium. Of particular importance are ions such as sodium, potassium, or calcium. Their controlled exchange with the extracellular medium is crucial to action potentials in neurons, muscle contraction, etc. Since the cellular membrane is normally impermeable to ions, their exchange is facilitated by special proteins called the ion channels, which are embedded in the membrane and form gated microscopic pores.
The focus of our research is to better understand the function of these proteins and their nonequilibrium properties. We know they can detect certain environmental factors, such as changes in electric field, presence of cer
tain ligands or even mechanical stress, and can open or close in response to these factors (ion channel gating). This way they can control and regulate various physiological processes. We use the experimental technique of patch-clamping and recent advances in mathematics and statistical physics to better characterize and control the process of channel gating. We also look at the interaction of inorganic nanoparticles, e.g. multiferroic nanoparticles, with biological cells.
- Remote control of voltage-sensing biological macromolecules using multiferroic nanoparticles - with L. Malkinski (University of New Orleans)
- Conductance hysteresis in ion channels
- Experimental detection of nonequilibrium kinetic focusing in voltage-gated ion channels
- Optimization of wavelet-based voltage protocols for ion channel electrophysiology
- Quantum biology - modeling photosynthesizing complexes in plants - with L. Celardo (University of Puebla, MX)
Biophysics research combines experiments, computations, and theoretical analysis. Student researchers in the Biophysics lab can choose between doing experiments (preparing biological samples, performing patch-clamping experiments) and computational work (analysis of raw experimental data generated from patch-clamping experiments, simulation of ionic currents, and building models of channel gating kinetics). Our experiments use modern ion channel electrophysiology methods, such as the patch clamping technique. The lab is equipped with two patch-clamping stations, one of which is devoted to student training. Most of the numerical simulations are done using MATLAB.
Current student members of the lab:
- Ariel Hall (Physics'20)
- Cole Green (Physics'20)
- Megan Adamson (Physics'21)
- Kimiasadat Mirlohi (Physics'22)
Former lab members include:
- Kaough Baggett (Physics'18)
- Ilyes Benslimane (Physics'17)
- Antonio Ayala (Physics'17)
- Dustin Lindberg (Physics'14)
- Douglas Alexander (Physics'14)
- Michael Kammer (Physics'12)
- David Vumbaco (Physics'12)
- Warner Sevin (Physics'11)
- Stella von Meer (Physics'09)
- Meagan Relle (Biology'08)
Recent publications from the Lab:
- A. Kargol: "Introduction to Cellular Biophysics. Vol. II. From membrane transport to neural signaling". IOP Concise Physics, Morgan & Claypool Publishers 2019
- A. Kargol: "Introduction to Cellular Biophysics. Vol. I. Membrane transport mechanisms". IOP Concise Physics, Morgan & Claypool Publishers 2018
- A. Kargol, L. Malkinski, R. Eskandari, M. Carter, D. Livingston: “Cellular Defibrillation”: Interaction of Microscale Electric Field with Voltage Gated Ion Channels. J. Biol. Phys. (2015)
- A. Ayala, J.D. Alexander, A.U. Kargol, L. Malkinski, A. Kargol: Piezoelectric micro- and nanoparticles do not affect growth rates of mammalian cells in vitro. J. Bionanosci. 8 (2014) 309-312
- L. Ponzoni, G.L. Celardo, F. Borgonovi, L. Kaplan, A. Kargol: Focusing in Multiwell Potentials: Applications to Ion Channels. Phys. Rev. E 87 (2013) 852137
- A. Kargol: Wavelet-based protocols for ion channel electrophysiology. BMC Biophysics 6:3 (2013)
- A. Kargol, L. Malkinski, G. Caruntu: Biomedical applications of multiferroic particles. In: Advanced Magnetic Materials, InTech (2012)
- A. Kargol, M. Kargol: Passive transport processes in cellular membranes. In: Porous media: Applications in biological systems and biotechnology, Taylor and Francis Group, LLC (2011)
Dr. Grissom's research focuses on understanding sex differences in stress and anxiety across the lifespan, and how these differences impact learning and memory. Elevations in stress hormones at different critical developmental timepoints impact learning and memory in males and females differently. Increased anxiety resulting from stress exposure impacts learning style in a sex-specific manner as well. Dr. Grissom's current work uses rodent models to examine how elevations in stress hormones at different critical developmental periods impact measures of anxiety, and how this, in turn, alters learning and memory in males and females via changes in cell structure and function in related brain areas.
Dr. Evan Zucker, Professor of Psychology, studies the social and biological influences on the behavior and reproductive outcomes of nonhuman primates, as well as studying naturally-occurring patterns of human behavior (human ethology) and other aspects of social phenomena. His recent research has focused on the relationship between familial social status and life-history variables, as well as how indices of health in black howling monkeys are related to ecological factors, group composition factors, and reproductive status.
Dr. Patricia Dorn and a team of undergraduate researchers focus on interrupting transmission of Chagas disease, a leading cause of heart disease in Latin America, caused by the parasite Trypanosoma cruzi, and transmitted by kissing bugs. Through investigating the kissing bugs, they improve control methods and prevent people from becoming infected with this deadly parasite.
Chagas disease is contracted when infected kissing bugs bite humans or animals, opening a wound and producing contaminated waste that enters the wound or mucous membranes and ultimately into the bloodstream. Dorn says reactions to the bite itself can range from slight to extremely severe allergic reactions called anaphylaxis.
Once it enters the bloodstream, the Chagas parasite attacks muscle tissue, especially the heart, and may not be detected for 10 to 20 years. By that time, Dorn says the damage is done and the treatment options are limited.
Dorn and her student researchers have traveled to Guatemala to hunt for the kissing bugs in homes, caves and other locations in order to conduct the groundbreaking research. They've also spent time in Latin America creating educational films to educate villagers with step-by-step instructions for implementing an ecohealth approach to stopping the transmission of the deadly tropical disease. In Latin America, 7 to 8 million people are infected with the Chagas parasite and 30 to 40 percent of those are doomed to life-threatening heart disease.
Recent reserach conducted by the team shows people in the Southwestern U.S. are encountering the “Kissing bugs” that harbor the parasite that causes Chagas disease.
Although the bugs don’t infect humans at the same rate as they do in Latin America, the free-roaming kissing bugs in the desert Southwest frequently feed on humans outside the confines of their homes. For example, in a recent test eight bugs tested had all fed on humans and three of these were also infected with the Chagas-causing parasite Dorn and her team study—something the scientists can tell by looking at the DNA in the bugs’ abdomens. Because some of the bugs harbor the deadly parasite, this could represent an unrecognized potential for transmission of Chagas disease in the U.S.
Dr. Dupuis conducts research examining the effects of gaming and virtual reality on social behaviors including interpersonal violence and attitudes toward women. Her students have used virtual reality to examine concepts such as street harassment, sexism, embodiment, and aggression.
Philosophy senior Tara Malay and faculty member Dr. Leonard Kahn co-authored a review of Carol C. Gould's Interactive Democracy: The Social Roots of Global Justice for the journal Philosophy in Review. This project was sponsored by the Loyola University Collaborative Scholarship program. You can read the review here.
Malay begins graduate work in linguistics at the University of Jyväskylä in Finland this fall (2016).
Dr. Stephenson focuses on the synthesis of sensors based on supermolecular interactions, utilizing synthetic organic chemistry to form useful new materials; in other words, his main interest is in studying the interaction of molecules in order to make biocompatible sensing materials. Specifically, Dr. Stephenson's projects work to synthesize and study new sensors based on xanthene dyes such as rhodamine B. The sensors are formed by modifying existing dyes to have specific functions.
This year (2015-16) Robert Verchick a faculty member in the Environment Program has written and published a variety of works on Environmental Law. Robert has also spoke on many important environmental topics here in the US and internationally. See more detailed information below:
Disaster Law and Policy (WoltersKluwer/Aspen 3d ed. 2015) (with Daniel A. Farber, Jim Chen, & Lisa Grow Sun)
Feminist Legal Theory (NYU Press 2d ed. 2016) (with Nancy Levit and foreword by Martha Minow)
"Environmental Law", in Cuban Legal System, (Thomas Reuters Publishing, José Cot & Rolando Anillo eds., 2016) (in press)
"Disaster Law and Climate Change", in Climate Change Law, (Edward Elgar Publishing, Daniel A. Farber & Marjan Peeters eds., 2016)
"Natural Disaster and Climate Change", in International Environmental Law and the Global South: Comparative Perspectives, 491-507 (Shawkat Alam, Sumudu Atapattu, Carmen G.Gonzalez, & Jona Razzaque eds., Cambridge University Press 2015) (with Paul Govind)
Law Review Article
"Culture, Cognition, & Climate," 2016 University of Illinois Law Review -- (in press)
"Climate Change, Resilience, and Fairness: How Nonstructural Adaptation Can Protect and Empower Socially Vulnerable Communities on the Gulf Coast" (Center for Progressive Reform 2016) (with Carmen Gonzalez, et al.)
"Time for Communities to Face Climate Change," Advocate (New Orleans), Apr. 14, 2016
"VW and GM Scandals Show Why Regulation Matters," The Hill (Washington, D.C.), Sept. 30, 2015 (with Rena Steinzor)
"Katrina’s Lessons: Learned and Unlearned," Houston Chronicle, Aug. 28, 2015
Oxford University, All Soul’s College (Oxford, U.K.), Workshop: Regulating the Energy
Transition; presented "Lights Out: Energy, Resilience, & Fairness" (June 2016)
Law and Society Association Annual Meeting, panel; presented "Lights Out: Energy,
Resilience, and Fairness" (May 2016)
Law and Society Association Annual Meeting, panel; presented "Bridge Under Troubled
Water: Climate Resilience and Fairness" (May 2016)
Law and Society Association Annual Meeting, panel, “The Coming Era of Gender Inequality”
University of Kansas (Lawrence, KS), Symposium, "Justice in the Low-Carbon Transition,"
panelist (April 2016)
Loyola University New Orleans, Conference on Coastal Resilience (co-sponsored with
Oxfam America), Moderator, "Non-Structural Tools for Adaptation" (April 2016)
State of the Coast Conference (New Orleans, LA); presentation: “Climate Change, Resilience,
and Fairness” (April 2016)
Loyola University New Orleans (New Orleans, LA), Conference: Beyond the Levees
(sponsored by Loyola Center for Environmental Law, Oxfam America, and Center for
Progressive Reform); presentation: “Climate Change, Resilience, and Fairness” (April 2016)
University of Georgia (Athens, GA), Keynote Address at Red Clay Conference; presented
"Bridge Under Troubled Water: Climate Resilience and Transportation" (Feb. 2016)
Tulane University (New Orleans, LA), Environmental Law Summit, panelist; presented
"Culture, Cognition and Climate" (Feb. 2016)
Tulane University (New Orleans, LA), Environmental Law Summit, Moderator, "Waters of
the United States" (Feb. 2016)
University of Florida (Gainesville, FL), lecture "Climate and Coastal Retreat" (Jan. 2016)
University of Florida (Gainesville, FL), faculty colloquium "Culture, Cognition, and Climate"
Annual Meeting of Association of American Law Schools (New York, NY), panel,
“International Environmental Law and the North-South Divide: Crossroads of Economic,
Environmental, Human Rights, Energy, Food, Climate, and Sustainable Development Law”